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Scientist / Senior Scientist, Membrane Biochemistry
Altos Labs · San Francisco, CA · Posted 44 days ago
What You Will Contribute To Altos
As an individual contributor and Scientist in Discovery Science, you will advance Altos' scientific programs on brain aging and neurodegeneration using lipid and protein biochemistry approaches. The ideal candidate is an expert in membrane and lipid biology with experience purifying and structurally characterizing transmembrane or peripheral membrane-binding proteins. You will design and implement workflows that include construct design, expression and purification from mammalian recombinant sources, chromatography purification, membrane reconstitution, and vitrification for electron microscopy. You will also carry out biochemical activity assays and characterize biophysical properties of purified proteins, including hydrodynamic radius, binding kinetics, protein stability, and oligomerization. Experience with mass spectrometry, NMR, or X-ray crystallography of lipid-protein interactions is also of interest but not required. This position is in the Frost group at Altos Labs' Bay Area campus.
- Design expression constructs and perform recombinant cell culture for membrane protein and membrane-associated protein purification and characterization.
- Evaluate the purity, stability, and physical properties of purified proteins.
- Develop new protein activity assays and establish SOPs.
- Coordinate with CROs for material generation and analysis.
Minimum qualifications
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There are 18 open roles at Altos Labs right now. This role centers on Membrane Biochemistry, Lipid Biochemistry, Protein Purification, and Recombinant Protein Expression.
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